TY - JOUR JF - iums-rsj JO - RSJ VL - 2 IS - 2 PY - 2016 Y1 - 2016/9/01 TI - Anti-Tumor Effects of Resveratrol in Breast Cancer TT - اثرات ضد سرطانی رزوراترول بر سرطان پستان N2 - Breast cancer is the most common cancer in women worldwide. Current cancer treatments have multiple side effects, including damage to healthy cells, drug resistance and disease recurrence. Therefore, new therapeutic strategies are needed to achieve fewer toxicity and side effects. Several studies suggest that phytochemicals could be considered as appropriate choices for cancer prevention and treatment. Resveratrol (trans-3,5,4-trihydroxystilbene) is a polyphenol found in many plant species such as grapes, raspberries, mulberries, peanuts and blueberries, containing a wide range of health benefits. Resveratrol not only induces apoptosis of tumor cells and inhibits inflammatory factor NF-κB, but also inhibits some of estrogen-receptor isoforms and prevents the progression of cancer. Therefore, based on the available studies, resveratrol can be considered as one of the most promising candidates for cancer prevention and treatment and could be used after further investigations. SP - 32 EP - 40 AU - Hasanpour, Zahra AU - Amiri, Fatemehsadat AD - KW - Resveratrol KW - Breast Cancer KW - Apoptosis KW - NF-κB KW - Phytoestrogen UR - http://rsj.iums.ac.ir/article-1-43-en.html ER -