Background: Today Ginger in fresh and dried form is used as a spice around the world. In the past, Ginger in the treatment of various diseases, including arthritis, neurological diseases, inflammation, asthma, stroke, insomnia, diabetes and so on was consumed. It seems that Ginger can reduce inflammation in this disease.

Materials and Methods: We searched in PubMed database until 2015, using the following keywords: inflammation and Ginger, and so 78 clinical trials, animal and human studies were included in this investigation.

Results: Ginger extract with the antioxidant and anti-inflammatory ingredients such as 6 Gingerols, 6-Shogoals, Zhingerol, and etc can reduces inflammatory factors such as inflammatory cytokines and chemokines through their effects on inflammatory, antioxidant, and serotonin mechanisms, reducing enzyme antioxidant and useful in reducing inflammatory disease and its complications, and treatment.

Conclusions: Ginger can be useful in the treatment of inflammatory chronic diseases such as Fatty Liver, Asthma, Cancer and Arthritis through anti-inflammatory and antioxidative mechanisms.