Introduction: Nurses are working with groups such as job stress and fatigue of their common problems and in long year may reduce individual strength. The aim of this study was to investigate the association between The relationship between individual strength with job stress in nurses of lorestan city. Methodology: This descriptive - cross sectional study was carried out in 1394 on 100 nurses in Lorestan. The Checklist for Individual Strength(CIS) is an instrument for measuring fatigue and job stress questionnaire was used. Using the Pearson correlation coefficient, multiple linear regression analysis and t- Independent and Software SPSS20 was examined. Results: Pearson correlation coefficient showed that there is an inverse relationship between job stress score and total score of Checklist for Individual Strength(CIS)(r= - 0.435, p<0.001). Also, there are direct effect between job stress score with fatigue sensation (r=0.3, p<0.003), but an inverse relationship between the nurses' job stress and the motivation of areas(r= - 0.385, p<0.001), Concentration(r= - 0.377, p<0.001) and physical activity(r= - 0.202, p<0.04). There are inverse relationship between work experience and fatigue sensation(r= - 0.24, p<0.02) and direct relationship with concentration score(r= 0.202, p<0.04). Conclusion: The results show that job stress can indirectly effective on individuals strength in a population of nurses, also decreases the individual strength can be considered as a prognosis of job stress.